University of York Department of Chemistry
Dr Andrew F. Parsons
Publications

2006, 2005, 2004, 2003, 2002, 2001, 2000, 1999, 1998, 1997, 1996

Books

"An Introduction to Free Radical Chemistry"
A.F. Parsons, Blackwell Science, £27.50, ISBN 0632052929
[to order]
Book Cover
"Keynotes in Organic Chemistry"
A.F. Parsons, Blackwell Publishing,£13.99, ISBN 0632058161
[to order]
keynotes

Papers

2006top_of_page

Radical Addition Reactions of Phosphorus Hydrides: Tuning the Reactivity of Phosphorus Hydrides, the Use of Microwaves and Horner-Wadsworth-Emmons-type Reactions.
C.M. Jessop, A.F. Parsons, A. Routledge and D.J. Irvine, Eur. J. Org., in press.

A Short Approach to Chaetomellic Anhydride A from 2,2-Dichloropalmitic Acid: Elucidation of the Mechanism Governing the Functional Rearrangement of the Chlorinated Pyrrolidinon-2-one Intermediate.
L. De Buyck, C. Danieli, R. Galeazzi, F. Ghelfi, A. Mucci, M. Orena, U.M. Pagnoni, A.F. Parsons and F. Roncaglia, Tetrahedron, 2006, 62, 746.

2005top_of_page

Consecutive Approach to Alkenes that Combines Radical Addition of Phosphorus Hydrides with Horner-Wadsworth-Emmons-Type Reactions.
Mark P. Healy, Andrew F. Parsons, and James G. T. Rawlinson, Org. Lett., 2005, 7, 1597.

A New Route to (±)-erythro-Roccellic Acid and Chaetomellic Anhydride C Through Functional Rearrangement, promoted by n-Propylamine or Sodium Methoxide, of N-Propyl-3-chloro-4-dichloromethyl-3-dodecylpyrrolidin-2-one.
L. De Buyck, C. Danieli, F. Ghelfi, U.M. Pagnoni, A.F. Parsons, M. Pattarozzi and F. Roncaglia, Tetrahedron, 2005, 61, 2871.

Combined Dealkoxycarbonylation and Lactonisation of Unsaturated Malonates in Ionic Liquids.
M. F. Oswald, A.F. Parsons, W. Yang and M. Bowden, Tetrahedron Lett., 2005, 46, 8087.

Radion Reactions to Form Vinylphosphonothioates.
T. Hunt, A.F. Parsons and R. Pratt, Synlett, 2005, 2978.

Radical Addition Reactions of Diphenylphosphine Sulfide.
A.F. Parsons, D.J. Sharpe and P. Taylor, Synlett, 2005, 2981.

Probably the Most Important Reactions in the World.
A.F. Parsons, Chemistry Review, 2005, 15, 24.

2004top_of_page

Radical Reactions Using Decacarbonyldimanganese Under Biphasic Conditions.
N. Huther, P.T. McGrail and A.F. Parsons, Eur. J. Org. Chem., 2004, 1740.

A Simple and Efficient Route to Chaetomellic Anhydride A: a Potent Natural Ras Farnesyl-Protein Transferase Inhibitor.
L. De Buyck, R. Cagnoli, F. Ghelfi, G. Merighi, A. Mucci, U.M. Pagnoni and A.F. Parsons, Synthesis., 2004, 1680.

Phosphonyl Radical Addition to Enol Ethers. The Stereoselective Synthesis of Cyclic Ethers.
C.M. Jessop, A.F. Parsons, A. Routledge and D. J. Irvine, Tetrahedron Lett., 2004, 45, 5095.

Functional Rearrangement of Polychlorinated Pyrrolidin-2-ones to 5-Imino-lactams Promoted by n-Propylamine.
C. Danieli, F. Ghelfi, A. Mucci, U.M. Pagnoni, A.F. Parsons, M. Pattarozzi and L. Schenetti, Tetrahedron, 2004, 60, 11493.

The Magnificent Seven: Magic Bullets of the Twenty-First Century.
A.F. Parsons, Chemistry Review, 2004, 14, 12.

Polymerisation of Ethylenically Unsaturated Monomers.
B.C. Gilbert, R.J. Harrison, D.J. Irvine and A.F. Parsons, Patent Number, WO2004085494.


2003top_of_page

Manganese(III) acetate-mediated alkylation of β-keto amides: an enantio- and diastereo-selective approach to substituted pyrrolidinones.
G. Bar, A. F. Parsons and C. B. Thomas, Org. Biomol. Chem., 2003, 1, 373.

Cyclisation of dienes using phosphorus-centered radicals to form organophosphorus adducts
C. M. Jessop, A. F. Parsons, A.Routledge and D. Irvine, Tetrahedron Lett. , 2003, 3, 479

CAN-Mediated Oxidative Free Radical Reactions in an Ionic Liquid
G. Bar, F. Bini and A.F. Parsons, Synth. Commun., 2003, 33, 213.

Stereoselective Radical Reactions
G. Bar and A.F. Parsons, Chem. Soc. Rev., 2003, 32, 251.

Polymerization of Methyl Methacrylate Using Dimanganese Decacarbonyl in the Presence of Organohalides
B.C. Gilbert, R.J. Harrison, C.I. Lindsay, P.T. McGrail, A.F. Parsons, R. Southward and D.J. Irvine, Macromolecules, 2003, 36, 9020.

Metal-catalysed Radical Cyclisations Leading to N-Heterocycles: New Approaches to Gabapentin and Pulchellalactam
J.S. Bryans, N.E.A. Chessum, N. Huther, A.F. Parsons and F. Ghelfi, Tetrahedron, 2003, 59, 6221.

Radical Addition Reactions of Chiral Phosphorus Hydrides
C.M. Jessop, A.F. Parsons, A. Routledge and D.J. Irvine, Tetrahedron: Asymmetry, 2003, 14, 2849.

An Efficient Route to Aliphatic 2,2-Dichloroaldehydes via Chlorination of Aldehydes or Alcohols with the System Cl2/Quaternary Ammonium Chloride
F. Bellesia, L. De Buyck, F. Ghelfi, U.M. Pagnoni, A.F. Parsons and A. Pinetti, Synthesis, 2003, 2173.

Hydro-de-halogenation and Consecutive Deprotection of Chlorinated N-Amido-pyrrolidin-2-ones with Raney-Ni: An Effective Approach to Gabapentin
R. Cagnoli, F. Ghelfi, U.M. Pagnoni, A.F. Parsons and L. Schenetti, Tetrahedron, 2003, 59, 9951.

A Radical Alternative to Ions
A.F. Parsons, Educ. Chem., 2003, 40, 42.

Modern Approaches to Organic Synthesis: New Tricks for Stacking Bricks
A.F. Parsons, Chemistry Review, 2003, 12, 2.

A Polymer-Supported Organic Reaction: Seeing is Believing
E. Hailstone, N. Huther and A.F. Parsons, J. Chem. Educ., 2003, 80, 1444.

Classifying Organic Reactions
A.F. Parsons, Chemistry Review
2003, 13, 8.

Photochemical Alkylation Reactions; N. Huther and A.F. Parsons, CRC Handbook of Organic Photochemistry and Photobiology; 2nd Edition
Ed. W.M. Horspool and F. Lenci, CRC Press: Boca Raton, FL, 2003.



2002top_of_page

New Free Radical Initiators Bearing Metal-Metal, Metal-Hydrogen and Non-Metal-Hydrogen Bonds
B.C. Gilbert and A.F. Parsons, J. Chem. Soc., Perkin Trans. 2 , 2002, 367.

Biphasic Manganese Carbonyl Reactions: A New Approach to Making Carbon-Carbon Bonds
N. Huther, P.T. McGrail and A.F. Parsons, Tetrahedron Lett , 2002, 43 , 2535.

Tributyltin Hydride-Mediated Radical Cyclisation of Carbonyls to Form Functionalised Oxygen and Nitrogen Heterocycles
J. Bentley, P.A. Nilsson and A.F. Parsons, J. Chem. Soc., Perkin Trans. 1 , 2002, 1461

1,2-Reduction of α,β-Unsaturated Hydrazones Using Dimethylamine-borane/p-Toluenesulfonic Acid: An Easy Route to Allyl Hydrazines
M.E. Casarini, F. Ghelfi, E. Libertini, U.M. Pagnoni and A.F. Parsons Tetrahedron , 2002, 58 , 7925.

A Race Against Tin
A.F. Parsons, Chemistry in Britain , 2002, 38 , 42

Manganese(III) Acetate-Mediated Alkylation of 1,3-Dicarbonyls to Form Tricarbonyl Compounds Bearing a Quaternary Carbon Centre
G. Bar, A.F. Parsons and C.B. Thomas, Synlett , 2002, 1069

Tandem Radical Cyclisation and Translocation Approaches to Biologically Important Mitomycin Ring Systems
G.M. Allan, A.F. Parsons and J-F. Pons, Synlett , 2002, 1431



2001top_of_page
Intramolecular Diels-Alder Cycloaddition of N -Allyl- N -[Methyl-(2-Furyl)] Amides: First Step of a New Route Towards the Synthesis of a Densely Functionalized Pyrrolizidine ring
Ghelfi  F, Parsons A.F, Tommasini D and Mucci A, Eur. J. Org. Chem ., 2001, 1845

Manganese(III) acetate mediated radical reactions leading to araliopsine and related quinoline alkaloids
Bar G, Parsons A F,  and Thomas C B, Tetrahedron , 2001, 57 , 4719-4278

The synthesis of functionalised β- and γ-lactams by cyclisation of enamides using copper(I) or ruthenium(II)
Bryans J S, Chessum N E A, Parsons A F and Ghelfi F,  Tetrahedron Lett. , 2001, 42 , 2901-2905

Radical cyclisation reactions involving phosphonyl radicals: the use of phosphites and phosphine oxides as alternatives to tributyltin hydride
Barks J M, Gilbert B C, Parsons A F and Upeandran B, Tetrahedron Lett ., 2001, 42 , 3137-3140

Free Radical Cyclisation of Enamides Leading to Biologically Important γ-Lactams
Parsons A, C.R Seances Acad. Sci. Ser ., 2001, 4, 391 (review)

Manganese(III) acetate mediated radical reactions in the presence of an ionic liquid
Bar G, Parsons A F and Thomas C B, Chem. Commun ., 2001, 1350

A Photochemical Approach to Phenylalanines and Related Compounds by Alkylation of Glycine
Knowles H S, Hunt K and Parsons A F, Tetrahedron , 2001, 57 , 8115

Addition of Trichloromethyl Radicals to Alkenes: The Use of Phosphites as Hydrogen-Atom Donors in Intermolecular Radical Additions
Barks J M, Gilbert B C, Parsons A F and Upeandran B, Synlett , 2001, 1734

It's a Radical World
Parsons A F, Chemistry Review , 2001, 11 , 18

Antioxidants (In Pictures).
Parsons A F, Chemistry Review , 2001, 11 , 16



2000top_of_page

The synthesis of α,β–dehydroamino acid esters from hydroxyamino esters using haloacetyl halides
Goodall K and Parsons A F, J. Chem. Res ., 2000, (S) 54-55; (M), 0312-0326

Desulfonylation of amides using tributyltin hydride, samarium diiodide or zinc/titanium tetrachloride. A comparison of methods
Knowles H S, Parsons A F, Pettifer R M and Rickling S, Tetrahedron , 2000, 56 , 979-988

Initiation of radical cyclisation reactions using dimanganese decacarbonyl. A flexible approach to preparing 5-membered rings
Gilbert B C, Kalz W, Lindsay C I, McGrail P T, Parsons A F and Whittaker D T E, J. Chem. Soc., Perkin Trans. 1 , 2000, 1187-1194

Preparation of N-heterocycles by radical cyclisation of enamides mediated by manganese(III) or copper(I). A comparison of cyclisation methods
Davies D T, Kapur N and Parsons A F, Tetrahedron , 2000, 56 , 3941-3949

Tributyltin hydride-mediated tandem reactions of dehydroalanines leading to a-substituted pyroglutamates
Baker S R, Goodall K, Wilson M and Parsons A F, J. Chem. Res ., 2000, (S) 312-313; (M), 0837-0852

N,N-Dimethylamino-2-pyrrolidinones from the rearrangement of N-allyl-N’,N’-dimethyl-2,2-dichlorohydrazides promoted by CuCl-N,N,N’,N’-tetramethylethylendiamine
Ghelfi F and Parsons A F, J. Org. Chem ., 2000, 65 , 6249-6253

Radical cyclisation reactions leading to polycyclic alkaloids related to the Amaryllidaceae and Erythrina alkaloids Parsons A F and Williams D A J, Tetrahedron , 2000, 56 , 7217-7228

An efficient and extremely mild method for protecting alcohols as 2-tetrahydrofuranyl ethers
Barks J M, Gilbert B C, Parsons A F and Upeandran B, Tetrahedron Lett ., 2000, 41 , 6249-6252

Photochemical alkylation of glycine leading to phenylalanines
Knowles H S, Hunt K and Parsons A F, Tetrahedron Lett ., 2000, 41 , 7121-7124

A radical approach to araliopsine and related quinoline alkaloids using manganese(III) acetate
Bar G, Parsons A F and Thomas C B, Tetrahedron Lett ., 2000, 41 , 7751-7755

Tributyltin hydride-mediated radical cyclisation of aldehydes and unsaturated ketones: the synthesis of hydroxy tetrahydrofurans, chromanols and related compounds
Bebbington D, Bentley J, Nilsson P A and Parsons A F, Tetrahedron Lett ., 2000, 41 , 8941-8945



1999top_of_page

Efficient radical coupling of organobromides using dimanganese decacarbonyl
Gilbert B C, Lindsay C I, McGrail P T, Parsons A F and Whittaker D T E, Synth. Commun ., 1999, 29 , 2711-2718

Tandem radical cyclisation of enamides mediated by tin hydride; pyrrolizidinone or indolizidinone ring formation
Baker S R, Burton K I, Parsons A F, Pons J-F. and Wilson M, J. Chem. Soc., Perkin Trans. 1 , 1999, 427-436

The influence of benzylic protection and allylic substituents on the CuCl-TMEDA catalysed rearrangement of N-allyl-N-benzyl-2,2-dihaloamides to γ-lactams. Application to the stereoselective synthesis of pilolactam
Ghelfi F, Bellesia F, Forti L, Ghirardini G, Grandi R, Libertini E, Montemaggi M C, Pagnoni U M, Pinetti A, De Buyck L and
Parsons A F, Tetrahedron , 1999, 55 , 5839-5852

Efficient radical cyclisation of secondary amides: an enantioselective synthesis of phenyl allokainoid
Bryans J S, Large J M and Parsons A F, Tetrahedron Lett ., 1999, 40 , 3487-3490

Radical cyclisations promoted by dimanganese decacarbonyl: a new and flexible approach to 5-membered
N-heterocycles
Gilbert B C, Kalz W, Lindsay C I, McGrail P T, Parsons A F and Whittaker D T E, Tetrahedron Lett ., 1999, 40 , 6095-6098

Efficient tin hydride–mediated radical cyclisation of secondary amides. Part 1. Synthesis of a variety of substituted pyrrolidinones
Bryans J S, Large J M and Parsons A F, J . Chem. Soc., Perkin Trans. 1 , 1999, 2897-2904

Efficient tin hydride–mediated radical cyclisation of secondary amides leading to substituted pyrrolidinones. Part 2. Application to the synthesis of aromatic kainic acid analogues
Bryans J S, Large J M and Parsons A F, J. Chem. Soc., Perkin Trans. 1 , 1999, 2905-2910

Copper(I) reactions in N–heterocycle synthesis: efficient preparation of substituted pyrrolidinones
Davies D T, Kapur N and Parsons A F, Tetrahedron Lett ., 1999, 40 , 8615-8618



1998top_of_page

A radical approach to debenzylation of amides
Baker S R, Parsons A F and Wilson M, Tetrahedron Lett ., 1998, 39 , 331-332

Synthesis of hydroxy pyrrolidines and piperidines via free-radical cyclisations
Parsons A F and Pettifer R M, J. Chem. Soc., Perkin Trans. 1 , 1998, 651-660

Radical reactions leading to substituted pyroglutamates
Baker S R, Parsons A F and Wilson M, Tetrahedron Lett ., 1998, 39 , 2815-2818

Manganese(III) reactions in N-heterocycle synthesis: the preparation of substituted pyrrolidinones
Davies D T, Kapur N and Parsons A F, Tetrahedron Lett ., 1998, 39 , 4397-4400

Tandem radical cyclisations leading to indolizidinones and pyrrolizidinones
Baker S R, Parsons A F, Pons J-F. and Wilson M, Tetrahedron Lett ., 1998, 39 , 7197-7200

Radical cyclisation of N-(cyclohexenyl)acrylamides: synthesis of bicyclic N-heterocycles
Parsons A F and Williams D A J, Tetrahedron , 1998, 54 , 13405-13420



1997top_of_page

A diastereoselective radical cyclisation approach to pyroglutamates
Goodall K and Parsons A F, Tetrahedron Lett ., 1997, 38 , 491-494

Desulfonylation of amides using samarium iodide
Knowles H, Parsons A F and Pettifer R M, Synlett , 1997, 271-272

Photo-decarboxylation of iron(III) porphyrin-amino acid complexes in aqueous solution
Gilbert B C, Lindsay Smith J R, Parsons A F and Setchell P K, J. Chem. Soc., Perkin Trans. 2 , 1997, 1065-1073

The synthesis of dehydroamino acids from pyruvic acid
Davies D T, Goodall K, Kapur N, O'Brien M and Parsons A F, Synth. Commun ., 1997, 27 , 3815-3822

Radical cyclisation of amino aldehydes leading to hydroxy pyrrolidines and piperidines
Parsons A F and Pettifer R M, Tetrahedron Lett ., 1997, 38 , 5907-5910



1996top_of_page

A radical approach to N-desulfonylation
Parsons A F and Pettifer R M, Tetrahedron Lett ., 1996, 37 , 1667-1670

Recent developments in kainoid amino acid chemistry
Parsons A F, Tetrahedron , 1996, 52 , 4149-4174

A radical cyclisation approach to pyroglutamates
Goodall K and Parsons A F, Tetrahedron , 1996, 52 , 6739-6758

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Last Updated: 6th January 2006. These pages are maintained by Izzi Montgomery.
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