Alastair Droop, Philip Garnett, Fiona A. C. Polack, Susan Stepney.
Multiple model simulation: modelling cell division and differentiation in the prostate.

CoSMoS workshop, Paris, France, August 2011 , pp.79-111, Luniver Press 2011

Abstract:

We describe an approach to building a hybrid multi-scale model, using a Petri net model for the top layer, and object-oriented models at the lower layers, with a rigorous definition of how the layers compose. We apply this approach to building a model of prostate cell division and differentiation, with each model layer describing the processes at a suitable level of abstraction. This provides a systematic modular approach to modelling and to model validation, allowing use of diverse modelling techniques in developing multi-scale models with no loss of rigour or validity. We use this prostate model to develop a prototype simulation, and demonstrate that it is capable of simulating biologically-relevant numbers of cells.

@inproceedings(SS-CoSMoS11-pmodel,
  author = "Alastair Droop and Philip Garnett and Fiona A. C. Polack and Susan Stepney",
  title = "Multiple model simulation:
           modelling cell division and differentiation in the prostate",
  pages = {79-111},
  crossref = "CoSMoS11"
)

@proceedings(CoSMoS11,
  editor = "Susan Stepney and Peter Welch and Paul S. Andrews and Carl G. Ritson",
  title = "Proceedings of the 2011 Workshop on Complex Systems Modelling and Simulation,
           Paris, France, August 2011",
  booktitle = "Proceedings of the 2011 Workshop on Complex Systems Modelling and Simulation,
               Paris, France, August 2011",
  publisher = "Luniver Press",
  year = 2011
)