Directory of randomisation software and services
This is a directory of randomisation software and services for clinical trials,
including both simple do-it-yourself software and 24 hour telephone
randomisation services. It is intended to help people planning and seeking
funding for clinical trials.
If you know of other software or services which should be included, please
email Martin Bland
firstname.lastname@example.org and they will be added to the directory. If your
service is listed here and you do not want it to be, please email Martin Bland
and you will be removed. This is an updated version of the
Directory of randomisation software and services previously held at
St. George's Hospital Medical School.
This directory is partial. Exclusion from it does not imply that the service
is inferior in any way, just tell us who you are and we will include you.
Inclusion in it does not imply that the service has been approved by us. We
take responsibility only for getting the links right.
is an old MS-DOS program by Martin Bland, which is free. It is suitable for small
scale trials. It does blocked and unblocked allocations and random sampling.
Randomisation is found under main menu option 8. It prints simple lists of
random allocations. For stratified randomisation, just print a blocked
randomisation list separately for each stratum.
For Windows 7, from which Microsoft have treacherously deleted MS-DOS,
a program called
dosbox has been used successfully to run clinstat.
Minim is an MS-DOS program by Stephen Evans, Simon Day and
Patrick Royston. It does allocation by minimisation very effectively and is
free. The authors have generously allowed us to put it on this site for
downloading. It runs interactively through your study, as this is how
For Windows 7, from which Microsoft have treacherously deleted MS-DOS,
a program called
dosbox has been used successfully to run mimim.
Randomization.com is a free on-line
randomisation program. It randomises while you wait. It prints simple lists
of random allocations.
QuickCalcs, a free online calculator for scientists, offers simple random
allocation into equal-sized groups.
Experimental Design Generator And Randomiser, is a free on-line randomisation
program by James K. M. Brown (John Innes Centre). This is designed for
agriculture, and does Latin squares and split plots as well as simple
randomisation. It randomises while you wait. It prints lists of random
Stata is a commercial statistical analysis
program. There is an add-on called "ralloc", written by P. Ryan, that does
blocked randomization, stratified randomization, or both.
Stata is a great program for analysis, though you would not buy it just to
randomise. In the UK, Stata is supplied by
Registration-Randomisation Software is a web-based package produced by the
Netherlands Cancer Institute and the UK Medical Research Council Cancer Trials
Office. It is free and runs through your study interactively.
KEYFINDER by Pete Zemroch is a menu-driven interactive program suitable for
statisticians. It produces factorial designs, including blocked and/or
fractional-replicate designs with user-specified confounding and aliasing
properties. KEYFINDER is available free of charge. (This link also leads to
other advanced statistical design programs.)
Iain Buchan's programme StatsDirect
carries out randomisation into two groups and in matched pairs, among many
other statistical functions. The software is semi-commercial, in that the
revenue is used for more research in computational statistics, but the cost is
Random Allocation Software
by Dr. Mahmood Saghaei, Isfahan University of Medical Sciences, Iran, is a free
downloadable program which carries out simple and blocked random allocation.
by Geoffrey C. Urbaniak and Scott Plous is a free net-based program which
generates sequences of random digits which can be used for a variety of
randomisation tasks. It can download randomisations in Excel format.
outcome-adaptive randomization program for clinical trials from the
M. D. Anderson Cancer Center, University of Texas.
This is available with much other statistical software on this site,
including sample size and predictive probability interim analysis
software for randomized trials.
TENALEA (Trans European Network for Clinical Trials Services)
is a free online randomisation program and much more.
TENALEA has been developed by the Netherlands Cancer Institute
and is currently in deployment phase, with a European Union grant.
This means that it can be offered free for non commercial use.
Etcetera is one of Joe Abramson's free
WinPepi programs for epidemiologists.
Randomisation is found under menu option A.
The program offers simple and balanced randomisation (unstratified or stratified),
balanced randomisation of successive blocks, an aid to minimisation,
and random sequencing of procedures.
It prints lists of allocations.
RANDOM.ORG provides several on-line
randomisation programs using random numbers generated by atmospheric noise,
rather than the pseudo-random number algorithms used in most randomisation programs.
It might not be the most suitable program for randomised trials,
but it is certainly worth a look.
is a free open source desktop application for managing the whole process of minimization.
The author says "With MinimPy all aspects of a minimization protocol can be configured and controlled.
It has optional network synchronization feature which uses a central SVN repository.
This is particularly useful for multi-center trials.
MinimPy program is written using Python programming language which is a
powerful platform-independent scripting language suitable for scientific and mathematical calculations.
The program is freely available for download under GPL license."
These provide trial support services including telephone randomisation. These
are not free. You must discuss your trial with the centre and agree their
involvement before applying for your grant. These services are not cheap. 10
pounds per patient randomised is typical. They also provide many other
collaborative services for trials. Some of these organisations have their
origins in academic research, others are purely commercial.
Telephone randomisation may be provided during normal working hours or 24 hours
per day. You should check what service you need and what the service provider
offers. You should also check what out-of-hours procedure they provide. This
might be a voice activated computer, a person sitting by the phone, or a phone
directed to someone doing something else.
York Trials Unit,
Dept of Health Sciences, University of York. This group works in collaboration with researchers on all
aspects of trial design and analysis, including telephone randomisation.
Birmingham Clinical Trials Unit
offers customised minimisation randomisation programs as well as a telephone
MRC/ICRF/BHF Clinical Trial Service Unit & Epidemiological Studies Unit,
University of Oxford, carries out large-scale collaborative trials.
The Clinical Trials Research Unit
(CTRU) at the University of Leeds offers a wide range of collaborative trial services.
The Health Services
Research Unit (HSRU) at the University of Aberdeen offers a 24-hour
automated telephone randomisation service. Please direct all enquiries to
Gladys McPherson email@example.com .
Clinical Trial Support Unit at the
University of Nottingham offers both web based and telephone based
randomization or minimization.
The King's Clinical Trials Unit at the
Institute of Psychiatry, King's College London, offers randomisation and other
trials services to mental health and neuroscience trials across the UK.
Trials Research Unit (CTRU), Faculty of Medical and Health Sciences,
University of Auckland, New Zealand offers 24 hour randomisation.
Clinical Trials Centre of the University of Sydney, Australia, provides a
randomisation service, available daily from 6 a.m. to 8 p.m. (24 hours a day
for acute cardiovascular trials).
Randomizer is a web-based online
randomisation service provided by Medical University of Graz.
A fee is payable for this service.
Duke Clinical Research Institute (DCRI) Duke University Medical Center,
Randomization: a 24-hour on-site, staffed randomization service with
interactive voice response system technology and emergency unblinding.
Randomization Systems and Services offer an interactive voice response system
for managing patient randomization during clinical trials, 24-hour.
Nottingham Clinical Research Limited
(NCRL) provides a broad range of services oriented to the Pharmaceutical
and Biotechnology industries. As well as an interactive voice response system
NCRL provide statistics, data management, monitoring and drug and materials
storage & distribution. Main expertise is in large cardiovascular outcome
trials, in excess of 5000 patients.
Covance InterActive Trial Management Systems offers randomisation by an interactive
voice response system, oriented towards the pharmaceutical industry.
The Sealed Envelope
is a web-based on-line random allocation system.
ClinPhone provides a service
oriented towards the pharmaceutical industry, offering data collection as well
as randomisation by phone.
ASCOPHARM offer a
variety of central randomisation systems for the pharmaceutical industry.
IDDI (International Drug Development Institute)
is a Belgian Central Service Randomization Provider with offices in France
and in the United States.
Since 1991, IDDI has developed an expertise in Phase I through IV clinical trials mainly
in oncology, ophthalmology and cardiovascular.
provides fully web-integrated Interactive Voice Response Systems (IVRS),
Electronic Data Capture (EDC) systems and a portfolio of web-enabled technology solutions
to streamline clinical trial management.
Thanks for the information to
John C. Nash,
and a couple of Google searches.
You can read more about setting up research projects in the
Statistics Guide for Research Grant Applicants.
It's all good, but you might want to go directly to the
Chapter on clinical trials.
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Last updated: 18 June, 2013.