Clinical Biostatistics: Mouse livers exercise, answer 1

1. What assumptions would we have to make about the data for these tests. Which one is clearly violated here?

Suggested answer

The assumptions of two sample t method are:

The assumptions of the large sample z method for two means are

The assumption which is clearly violated is that the observations are independent. We have 280 measurements from only three mice. The measurements on the same mouse may be more similar than they are to measurements from another mouse.

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